Expert Tip: Strengthen Your 340B Program with Regular Internal Audits for Compliance and Savings

TIP: Maximize the effectiveness of your 340B program through consistent internal audits, ensuring both compliance and enhanced savings.

Establishing and running an effective 340B program requires diligent oversight and dedicated compliance management. A key component in achieving success is the regular implementation of internal audits. These audits serve as a proactive measure, ensuring your organization’s adherence to all the necessary regulations and guidelines governing the 340B program. By routinely reviewing your program’s operations, you can promptly identify and address any potential compliance issues, preventing their escalation into more significant problems. This not only helps in avoiding potential fines and penalties but also ensures that your program is operating at its full potential.

In addition to ensuring compliance, internal audits can also help optimize savings within your 340B program. A thorough examination of your purchasing and dispensing practices allows for the identification of opportunities to enhance efficiency and reduce costs. This could include streamlining inventory management, negotiating more favorable pricing with suppliers, or uncovering possibilities to expand the program’s reach to serve more eligible patients. By implementing adjustments based on insights gained from internal audits, you can strengthen the financial sustainability of your 340B program. This also ensures its continued provision of essential services to underserved populations while maintaining compliance with all relevant regulations and guidelines.

Recent Articles

Pillr Health Acquires CaptureRx, Expanding Pharmacy Solutions to More Health Care Organizations

BOCA RATON, Fla. — May 19, 2026 — Pillr Health, a leading provider of software and tech-enabled services that optimize pharmacy operations, today announced it has acquired CaptureRx, a 340B technology and services organization based in San Antonio, Texas. The acquisition expands Pillr Health’s platform of pharmacy solutions to support more than 500 hospitals, health systems and federally qualified health centers (FQHCs) nationwide. 

With this acquisition, CaptureRx’s customers gain access to Pillr Health’s comprehensive suite of services designed to strengthen the performance of their pharmacy programs and 340B initiatives amid an increasingly complex regulatory environment. Pillr Health’s integrated platform of software, analytics and advisory services provides them with split billing, contract pharmacy administration, entity-owned pharmacy management, referral capture, compliance support and pharmacy optimization programs.  

Skip Devanny, chief executive officer of Pillr Health, who will lead the combined organization, said: “We are proud to welcome and serve the hospitals, health systems and community health centers that have been supported by CaptureRx for more than 20 years. They are the front door to care for millions of Americans, and we are committed to advancing their important work with the full strength of our pharmacy solutions and expertise.”  

With CaptureRx, Pillr Health will expand its ability to support covered entities in strengthening their pharmacy programs as they navigate mounting requirements for the 340B federal drug pricing program. This program enables eligible hospitals, health systems and FQHCs to purchase outpatient medication at significantly reduced prices, generating savings that fund care for uninsured, low-income and vulnerable patients. 

About Pillr Health 

Pillr Health is dedicated to transforming health care through cutting-edge solutions that enhance efficiency, optimize resources and improve patient outcomes. The company specializes in 340B program administration, helping hospitals and health systems maximize performance in the federal outpatient drug pricing program, which provides discounts to organizations serving uninsured, low-income and vulnerable patient populations. Headquartered in Boca Raton, Florida, Pillr Health serves more than 500 health care organizations nationwide through its comprehensive platform of software, analytics and managed pharmacy offerings. 

Pillr Health and Sam’s Club Partner to Launch a New Era of 340B Contract Pharmacy Services

Pillr Health is proud to announce a new national relationship with Sam’s Club.

Beginning January 1, 2026, Sam’s Club will use Highbridge, the 340B data-processing technology developed by Pillr Health, as its platform for managing all 340B contract pharmacy relationships.

This collaboration marks Sam’s Club’s first participation in the 340B program, creating new opportunities for Covered Entities to expand their networks and capture untapped program value. By leveraging Highbridge, Sam’s Club will deliver standardized, scalable, and compliant 340B services across its pharmacy network: ensuring consistency, transparency, and growth potential for partners nationwide.

Expanding Access, Empowering Growth

Through this partnership, Sam’s Club and Pillr Health are delivering a scalable technology framework that streamlines 340B operations and strengthens collaboration across the program’s national network.

“This partnership represents a pivotal step forward for both organizations,” said Skip Devanny, CEO of Pillr Health. “By combining Sam’s Club’s national reach with Pillr’s advanced technology, we’re enabling a new era of collaboration and value creation across the 340B ecosystem.”

A Shared Commitment to the 340B Mission

At its core, this partnership is about more than technology. It is about advancing the mission of 340B by expanding access, improving affordability, and empowering providers to reinvest in patient care.

Through this collaboration, Sam’s Club and Pillr Health are building a strong foundation for sustained 340B growth, helping safety-net providers strengthen compliance, increase savings, and extend their impact in the communities that need it most.

Expert Tip: Maximize 340B Savings by Manually Pulling in Rejected and Qualified Claims

Manually pulling in rejected and qualified claims in the TPA database is a critical step in capturing eligible 340B savings that may have been missed due to unmatched prescription data. Claims can fail to match automatically to an EMR (Electronic Medical Record) or ERX (Electronic Prescription) record due to discrepancies in provider documentation, timing issues, or data entry errors. By reviewing and manually adjudicating these claims, covered entities (CEs) can identify encounters that still meet 340B eligibility requirements but were not captured through automated matching. This practice ensures the entity maximizes its 340B benefit while maintaining program compliance.

Furthermore, this manual reconciliation process supports stronger audit preparedness and data integrity. By documenting the rationale for qualifying claims and ensuring proper linkage to eligible encounters, CEs can provide a defensible audit trail. It also helps identify patterns in rejected claims that may point to workflow or system issues, allowing for targeted improvements. Ultimately, consistently reviewing and processing unmatched claims manually helps optimize program performance while upholding the accuracy and accountability essential in 340B operations.

Ready to get started?

Ready to get started?

The Pillr Health team is here to empower your 340B program, and beyond. Reach out at the link below.

The Pillr Health team is here to empower your 340B program, and beyond. Reach out at the link below.

Ready to get started?

The Pillr Health team is here to empower your 340B program, and beyond. Reach out at the link below.